Plasma Protein Fingerprinting for the Diagnosis of Small Intestinal Neuroendocrine Tumors (siNETs)


Introduction: siNETs are notoriously difficult to diagnose, especially in an early stage.

Aim(s): The EXPLAIN study aimed to investigate 92 plasma proteins (PP), previously shown to be cancer related, in an attempt to find new biomarkers for the diagnosis of siNETs.

Materials and methods: This non-interventional exploratory study in the nordic countries analysed 146 patients with siNET from 17 hospitals and 144 age and sex matched controls (all with written consent). Exclusion criteria were previously treated for NET, other malignant diseases, chronic inflammatory disease, kidney or liver failure. Blood samples (4 ml) were obtained at first visit. Samples analysis used the Proseek Multiplex Oncology II assay to measure relative levels of the 92 cancer related SP.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kjellman M

Authors: Kjellman M, Knigge U, Welin S, Grønbæk H, This-Evensen E,

Keywords: NET biomarker diagnosis,

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