Precision medicine in pancreatic MiNEN and other rare pancreatic histologies – A case series from Verona University Hospital

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Introduction: Rare tumors of the pancreas represent orphan neoplasms. Better knowledge of their biology will allow more effective treatments to be offered to affected patients.

Aim(s): The Next Generation Sequencing (NGS) Analysis approach represents in this context the current most effective tool for precision medicine.

Materials and methods: In this case series we included 21 patients affected by rare pancreatic tumors and treated at our Centre. Mixed neuroendocrine non-neuroendocrine (MiNEN; n=3), squamous cell carcinomas (n=4), ganglia and paraganglia tumors (n=2) together with acinar ones (n=7) are the most prevalent rare histologies. Oncocytic (n=1), pseudopapillary (n=2) and anaplastic (n=1) carcinomas were also included. NGS analysis was performed by FoundationONE® CDx (n=5) or in-house NGS assay (n=16). Clinical data were collected.

Conference:

Presenting Author: Trevisani E

Authors: Trevisani E, Mafficini A, Benini L, Borghesani M, Rossi A,

Keywords: Precision medicine, rare pancreas, NGS, gene mutation, MiNEN,