Preliminary Evaluation of Influence of Different Targeted Drugs of Vascular Endothelial Growth Factor Signaling Pathway on the Proliferation of Neuroendocrine Neoplasm Cell Lines

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Introduction: Sunitinib and bevacizumab are intracellular and extracellular inhibitor of vascular endothelial growth factor(VEGF) pathway respectively, the influence of both of which on the proliferation of neuroendocrine neoplasm (NEN) cell lines in vitro was not known yet.

Aim(s): To evaluate the influence of sunitinib and bevacizumab on the proliferation of neuroendocrine neoplasm cell lines in vitro.

Materials and methods: Human bronchial carcinoid cell line NCI-H727 and pancreatic neuroendocrine neoplasm cell line QGP-1 were treated with sunitinib and bevacizumab of different concentrations, cell proliferation and VEGF signaling were detected.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Zhang Y

Authors: Zhang Y, Chen L, Lin Y, Chen M, Chen J,

Keywords: neuroendocrine neoplasm, sunitinib, bevacizumab, VEGF pathway,