Pretherapeutic Predictors of Tumor Absorbed Dosimetry in Radionuclide Therapy for Metastatic Neuroendocrine Tumors

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Introduction: Pretherapeutic 68Gallium-DOTA-(0-Tyr3)-octreotate Positron Emission Tomography (68Ga-DOTATATE PET) standardised uptake value (SUV) has shown conflicting results in the prediction of tumour lesion absorbed dosimetry (TLAD).

Aim(s): We aimed to assess the correlation of pretherapeutic SUV parameters with TLAD in patients with metastatic neuroendocrine tumours (NET).

Materials and methods: Pretherapeutic 68Ga-DOTATATE PET-CT and intra-therapeutic TLAD measured with Single Photon Emission Computer Tomography (SPECT) after cycle one were retrospectively analysed. Patients were treated with 7.45GBq Lutetium octreotate radionuclide therapy.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Ladwa R, Pattison D, Smith J, Goodman S, Burg M,

Keywords: 68Ga-DOTATATE PET-CT, Tumor Dosimetry, SUV predictors,