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Primary Neuroendocrine Carcinoma of the Breast: A Diagnostic Approach to the Special Type of Breast Malignancy
Introduction: WHO classification from 2003 defines primary neuroendocrine carcinomas (NEC) of the breast as a group of tumors with expression of neuroendocrine markers in more than 50% of tumor cells. In the current WHO classification this category is renamed to “carcinomas with neuroendocrine features” without defined clear-cut of the percentage of tumor cells positive for neuroendocrine markers.
Aim(s): To evaluate diagnostic criteria for primary breast NEC.
Materials and methods: Histopathologic reports of patients with breast carcinoma in the last 10 years were analyzed; cases of breast NEC were selected and reviewed for the positivity for neuroendocrine markers, estrogen receptors (ER), progesterone receptors (PR), HER-2/neu and presence of in situ component.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Demirovic A
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