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Primary Neuroendocrine Carcinoma of the Breast: A Diagnostic Approach to the Special Type of Breast Malignancy


Introduction: WHO classification from 2003 defines primary neuroendocrine carcinomas (NEC) of the breast as a group of tumors with expression of neuroendocrine markers in more than 50% of tumor cells. In the current WHO classification this category is renamed to “carcinomas with neuroendocrine features” without defined clear-cut of the percentage of tumor cells positive for neuroendocrine markers.

Aim(s): To evaluate diagnostic criteria for primary breast NEC.

Materials and methods: Histopathologic reports of patients with breast carcinoma in the last 10 years were analyzed; cases of breast NEC were selected and reviewed for the positivity for neuroendocrine markers, estrogen receptors (ER), progesterone receptors (PR), HER-2/neu and presence of in situ component.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Demirovic A

Authors: Demirović A, Vranic S, Skenderi F, Peric Balja M, Ulamec M,

Keywords: breast cancer, special types, carcinoma with neuroendocrine features, neuroendocrine markers,

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