Primary tumor resection improves survival of gastrointestinal neuroendocrine carcinoma patients with non-resected liver metastases

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Introduction: The role of primary tumor resection (PTR) in the survival of gastrointestinal neuroendocrine carcinoma (GI-NEC) patients with liver metastases only remains poorly defined.

Aim(s): We aimed to investigate the impact of PTR on survival of GI-NEC patients with non-resected liver metastases.

Materials and methods: GI-NEC patients with a liver-confined metastatic disease diagnosed between 2016 and 2018 were identified in the National Cancer Database (NCDB). Multiple imputations by chained equations (MICE) were used to account for missing data, and the inverse probability of treatment weighting (IPTW) method was used to eliminate selection bias. Overall survival (OS) was compared by adjusted Kaplan–Meier curves and log-rank test with IPTW. IPTW-adjusted Cox proportional hazards models, followed with subgroup analyses by tumor characteristics, evaluated the impact of PTR on OS.

Conference:

Presenting Author: Chen Q

Authors: Chen Q, Li K, Rhodin K, Masoud S, Lidsky M,

Keywords: gastrointestinal neuroendocrine carcinoma, liver metastasis, primary tumor resection, national cancer database,