Prognostic significance of nodal micro metastases in patients with non-functioning pancreatic neuroendocrine tumors (NF-PanNETs)

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Introduction: Nodal metastases are one of the most powerful predictors of disease recurrence after surgery for non-functioning pancreatic neuroendocrine tumors (NF-PanNETs). However, the prognostic role of nodal metastases measuring <5 mm, defined as micro metastases, has been poorly investigated so far.

Aim(s): To compare clinico-pathological features and survival outcomes between patients with NF-PanNETs without nodal involvement (N0), with nodal micro metastases (microN+) and with nodal metastases (N+).

Materials and methods: Consecutive patients who underwent formal pancreatic resection for NF-PanNETs at San Raffaele Hospital (2018-2021) and were enrolled in the DETECTYON trial were considered (NCT03918759).

Conference:

Presenting Author:

Authors: Andreasi V, Partelli S, Muffatti F, Giannone F, Palumbo D,

Keywords: PanNET, nodal metastases, surgery, recurrence, micro metastasis,