Prognostic significance of nodal micrometastases in patients with non-functioning pancreatic neuroendocrine tumors (NF-PanNETs) – A survival analysis from a prospective observational study

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Introduction: Nodal metastases (N+) are one of the most powerful predictors of disease recurrence after surgery for non-functioning pancreatic neuroendocrine tumors (NF-PanNETs). However, the prognostic role of nodal metastases <5 mm, defined as micrometastases, has been poorly investigated so far.

Aim(s): The aim of this study was to compare clinico-pathological features and survival outcomes between patients with NF-PanNETs without nodal involvement (N0), with nodal micrometastases (microN+) and with nodal macrometastases (macroN+).

Materials and methods: Consecutive patients who underwent a formal pancreatic resection for NF-PanNETs at San Raffaele Hospital (Milan, Italy) between 2018 and 2021 and were enrolled in the DETECTYON trial were considered (NCT03918759).

Conference:

Presenting Author: Andreasi V

Authors: Andreasi V, Partelli S, Schiavo Lena M, Muffatti F, Battistella A,

Keywords: nodal metastases, micrometastases, surgery, prognosis, recurrence, pancreatic neuroendocrine,