Prognostic value of systemic inflammatory parameters in neuroendocrine tumour patients treated with peptide receptor radionuclide therapy – Preliminary results

#4665

Introduction: PRRT (177Lu-Dotatate) is a therapeutic option for advanced NETs (neuroendocrine tumours). Systemic inflammatory parameters, such as NLR, PLR, SII, and other ratios derived from complete blood counts, are considered prognostic markers in NETs and other malignancies.

Aim(s): This preliminary study aimed to analyse the association between selected systemic inflammatory parameters and the response to PRRT in NET patients.

Materials and methods: A retrospective study of NETs receiving PRRT in a single centre has been performed. Eleven NET patients (G1 or G2) have been included. Median age was 71 (range 28-81). Male predominance was observed (7/11=63.6%). These were small intestine (8/11=72.7%), pancreatic (1), rectal (1) NETs and lung carcinoid (1). Blood samples were collected before PRRT and four weeks and three months post-treatment (4 doses of 200 mCi 177Lu-Dotatate). NLR, MLR, PLR, SII, SIRI, RDW/platelets, MPV/platelets were calculated. The response to the treatment was assessed at 3 months post-therapy based on RECIST 1.1.

Conference:

Presenting Author: Maciejewski A

Authors: Maciejewski A, Komarnicki P, Musiałkiewicz J, Gut P, Ruchała M,

Keywords: neuroendocrine tumour, PRRT, systemic inflammatory parameter, PLR, prognostic biomarker,