Prognostic value of whole-body PET volumetric parameters extracted from 68Ga-DOTATOC PET/CT in well-differentiated neuroendocrine tumors

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Introduction: Functional imaging could have a key role as prognostic biomarker in well-differentiated neuroendocrine tumors (WD-NETs).

Aim(s): To evaluate the prognostic value of whole-body volumetric PET parameters extracted from 68Ga-DOTATOC PET/CT in patients with WD-NETs.

Materials and methods: We retrospectively analysed 68Ga-DOTATOC PET/CT in 84 patients (48M/36F, mean age=62.8yo) with histologically proven WD-NETs (51 G1, 30 G2 and 3 G3). Primary site were as follows: GEP-NETs(n=72), lung(n=9) and unknown(n=3). For each patient, all DOTATOC-avid lesions were segmented by 2 operators using a customized threshold based on the healthy liver uptake (SUVmax) using LIFEx 5.1, and the global somatostatin receptor expressing tumor volume (SRETVwb) and total lesion somatostatin receptor expression (TLSRE=SRETV*SUVmean) were calculated. Time to progression (TTP) defined as the time between PET imaging to the first event and overall survival (OS) were studied using Kaplan-Meier analysis. Cox regression model was used to evaluate predictors of progression.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Thuillier P

Authors: Thuillier P, Liberini V, Grimaldi S, Rampado O, Gallio E,

Keywords: neuroendocrine tumor, 68Ga-DOTATOC PET/CT, tumor burden, prognosis, somatostatin receptor expressing tumor volume, total lesion somatostatin receptor expression,