Proposal of New Imaging Criteria for Evaluating the Response of Liver Metastases to Systemic Treatments in Digestive Neuroendocrine Tumors (NET) as an Alternative to RECIST 1.1

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Introduction: RECIST 1.1 criteria have been challenged for the evaluation of treatment response in NET.

Aim(s): To explore alternative computed tomography (CT) response evaluation criteria in metastatic NET.

Materials and methods: We included patients with small-intestine (n=50) or pancreatic (n=54) well-differentiated NET with liver metastases (LM), who received systemic therapy as first two treatment lines in 14 expert centers. Baseline (+/- 1 month) and first reevaluation (within 6 months) contrast-enhanced CT scans were locally reviewed to measure LM diameter (5 LM) and density (arterial and portal phases, 2 LM). Multivariate Cox regression analyses explored which response criteria best correlated with progression-free survival (PFS), considering different thresholds of size or density decrease (10%, 20% or 30%) and number of measured LM (2, 3 or 5).

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: de Mestier L, Dromain C, Lamarca A, La Salvia A, Op de Beeck B,

Keywords: imaging criteria, response evaluation, CT scan,