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Prospective Observational Study 1 on the Prognosis of Patients with Unresectable Advanced Gastrointestinal and Pancreatic Neuroendocrine Tumors (PROP-UP 1 Study) in Japan


Introduction: No previous observational studies on the prognosis of advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) [pancreatic neuroendocrine neoplasms (PNENs) and gastrointestinal neuroendocrine neoplasms (GI-NENs)] exist in Japan.

Aim(s): We planned a retrospective and prospective observational study on the prognosis of patients with unresectable advanced GEP-NENs (PROP-UP 1 and 2). PROP-UP 1 is a retrospective multicenter study to estimate a cut-off value of Ki-67 index between G1 and G2. PROP-UP 2 is a prospective study to verify the results of PROP-UP 1. In this paper we analyzed the characteristics of patients registered to PROP-Up 1.

Materials and methods: PROP-UP 1 included individuals diagnosed with advanced (unresectable or recurrent after curative resection) GEP-NENs from January 2012 up to IRB approval. The primary endpoint is overall survival from diagnosis to last follow-up or death. The main secondary endpoint is to assess a cut-off value of Ki-67 index between G1 and G2.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Toriyama K, Hijioka S, Komoto I, Kobayashi N, Okusaka T,

Keywords: prop-up, japan, gep-nen,

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