Real-Life Data for Telotristat Ethyl in Resistant-to-Treatment Carcinoid Syndrome: Is It Efficacious in Carcinoid Flushing as Well?

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Introduction: Results from clinical trials with telotristat ethyl (TE) are really encouraging about its role in carcinoid syndrome-associated diarrhoea, however, its efficacy in flushing has been equivocal.

Aim(s): To assess the efficacy and safety of TE in patients (pts) with SBNEN, with resistant-to-treatment flushing and diarrhoea.

Materials and methods: Seventeen SBNEN pts treated with oral TE 250mg tds were included. All had ongoing symptoms, despite maximum doses of long-acting SA +/- daily sc Octreotide injections. Frequency of bowel movements (BM) and flushing were assessed in 1, 6 and 12 months. Urinary 5HIAA levels were assessed at 6 or 12 months.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Gertner J

Authors: Gertner J, Eastwood O, Furtado O'Mahony L, Quaglia E, McSweeney A,

Keywords: telotristat,