Reduction of serum insulin levels and diazoxide doses as an effect of PRRT in patients with severe hypoglycemia due to primary non-operative insulinoma

#3145

Introduction: Severe hypoglycaemia in a course of inoperable insulinoma may be life-threating and it is not always well controlled even by high doses of diazoxide, which in some cases cause a significant toxicity. Nowadays, other forms of effective therapy are not available - use of protein kinase inhibitors (everolimus, sunitynib) sometimes bring satisfactory effect but is often associated with the risk of serious side effects. Use of Peptide receptor radionuclide therapy (PRRT), characterized by relatively low toxicity, is not widely used.

Aim(s): Evaluation the PRRT effect on insulin levels in patients with primary inoperable insulinoma.

Materials and methods: 2 patients (male aged 42 with primary inoperable pancreatic tumor, female aged 25 with MEN 1 syndrome and hepatic metastases) were treated with PRRT (90Y/177Lu-DOTA-TATE in the dose 7.4GBq /m2) due to severe hypoglycemia in course of primary inoperable insulinoma.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Opalińska M

Authors: Opalinska M, Sowa-Staszczak A, Al Maraih I, Kostecka-Matyja M, Hubalewska-Dydejczyk A,

Keywords: PRRT, insulinoma, NEN,