Retrospective analysis of somatostatin receptors expression in cohort of thoracic neuroendocrine neoplasms with immunohistochemistry method or PET/CT Ga68 DOTA-TATE

#4540

Introduction: Somatostatin receptors (SSTRs) expression in cohort of thoracic neuroendocrine neoplasms (NENs) is still not fully described. We attempted to evaluate the SSTR expression by IHC and PET/CT with Ga68 DOTA-TATE, as well as the sensitivity of both methods.

Aim(s): 1) SSTR expression evaluation in thoracic NENs: neuroendocrine tumours G1, G2, G3 (NETs) and large-cell neuroendocrine carcinoma (LCNEC); 2) Assessment of discordance in identifying positive SSTR-status using IHC and PET/CT Ga68 DOTA-TATE.

Materials and methods: 156 patients (pts) with NENs (lung, thymus and mediastinum) included, regardless of stage.

Conference:

Presenting Author: Evdokimova E

Authors: Evdokimova E, Vorobeva M, Zhulikov Y, Markovich A, Gorbunova V,

Keywords: NEN, thoracic, SSTR, IHC, DOTATATE, lung, thymus, mediastinum, LCNC, NET,