Role of gastric mucosa evaluation in diagnostic of pancreatic neuroendocrine tumors functional status

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Introduction: Accessibility of high-precision imaging dramatically increased detection rate of small asymptomatic pancreatic neuroendocrine tumors (PanNETs). Functioning status is indication for surgical treatment with high perioperative risks, while increased level of NET markers could be associated with gastric mucosa atrophy or intake of proton pump inhibitors (PPI) and nor with tumor secretion.

Aim(s): Study of correlation between the tumor functional status and the presence of chronic atrophic gastritis.

Materials and methods: Data from NET registry of Moscow Clinical Scientific Centre of patients diagnosed with PanNET stage T1-2 under long-term active surveillance (no surgery or systemic treatment) were evaluated (n=105). Serum level of serotonin, gastrin and chromogranin A was studied. A level exceeding the upper limit of reference by at least two times was considered elevated. Patients underwent esophagogastroduodenoscopy, in case of mucosal atrophy anti-parietal cell antibodies were studied.

Conference:

Presenting Author:

Authors: Salimgereeva D, Feidorov I, Konyakhina A,

Keywords: PanNET, chronic atrophic gastritis, marker, OLGA, anti-parietal cell antibodies,