Selective internal radiation therapy for neuroendocrine liver metastases: Efficacy, safety and prognostic factors – A retrospective single institution study

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Introduction: Selective internal radiation therapy (SIRT) has shown good results in unresectable liver metastases from neuroendocrine neoplasms (NENLMs) with a high disease control rate (DCR) reported (Braat et al., 2019).

Aim(s): To assess retrospectively the efficacy and safety of 10y of SIRT for NENLMs.

Materials and methods: 50 consecutive pts with NENLMs who got SIRT from 2011 to 2021 in our center. Median age was 63 y, sex ratio (M/F) was 1.2. The 2 major NEN primary sites were pancreas (46%) and small intestine (36%). Histological NEN grades were 10%, 46% and 44% for grades 1, 2 and 3 respectively. Primary endpoint was objective response (OR) and DCR (OR+SD) by RECIST 1.1 at 2, 4 and 12 months (m). Secondary endpoints were overall survival (OS), liver progression-free survival (liver-PFS), clinical response (NEN-related symptoms improvement) and safety.

Conference:

Presenting Author: Borbath I

Authors: Briol D, Cerrati A, Annet L, Danse E,

Keywords: SIRT, liver metastases, Prognostic factor, safety,