Somatostatin Analogs for Pancreatic Neuroendocrine Tumors: Is There Any Benefit When Ki-67 Is ≥ 10%?

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Introduction: The antiproliferative effect of first-line long acting somatostatin analogs (SSA) in advanced gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) was shown in the PROMID and the CLARINET trials. Efficacy data in pancreatic NETs (PanNETs) with Ki-67 ≥ 10% are limited.

Aim(s): To describe the efficacy and toxicity of first-line SSAs in a series of advanced, well-differentiated PanNETs with Ki-67 ≥ 10%.

Materials and methods: Retrospective, multicentre analysis including patients treated between 2014-2018 across 9 centers of the NET CONNECT Network. The primary aim was progression-free survival (PFS); toxicity and overall survival (OS) were secondary aims.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Merola E

Authors: Merola E, Alonso Gordoa T, Zhang P, Al-Toubah T, Pelle E,

Keywords: Pancreatic NET, Somatostatin Analogs, Grade 2 and 3, Safety, Efficacy,