Specific MicroRNA Profiles are Associated with Pathological Features in Lung Carcinoids

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Introduction: Data on miRNA expression in lung carcinoids are scarce.

Aim(s): To analyze miRNA expression profiling in lung carcinoids as compared to clinical and pathological features.

Materials and methods: Seven-hundred and twenty miRNAs were analyzed using PCR-based array method in a pilot series of 12 lung carcinoids. The significance of these miRNAs was confirmed by hierarchical clustering and the five miRNAs more significantly down-regulated in metastatic carcinoids (miR 409-5p, miR 409-3p, miR 185, miR 129-5p and miR 431-5p) were validated in 37 cases (22 TCs, four with lymph node metastasis and 15 ACs, seven with lymph node metastasis), and in 10 high grade neuroendocrine carcinomas.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Volante M

Authors: Rapa I, Votta A, Felice B, Righi L, Giorcelli J,

Keywords: lung, carcinoid, miRNA,