Subtype-specific landscape of splicing-associated neoantigens and mutations in pancreatic neuroendocrine tumors

#3757

Introduction: In pancreatic neuroendocrine tumors (PanNETs), there has recently been advancement in understanding the heterogeneity (metastases-like primary; MLP-1/2, intermediate, and insulinoma subtypes) and immunological landscapes. Immunotherapies provide modest therapeutic benefits to patients, which may be linked to low mutational neoantigen loads in PanNETs.

Aim(s): Hence, understanding the landscape of neoantigens derived from mutations and RNA splicing in subtypes is required.

Materials and methods: rnavar and IsoformSwitchAnalyzeR were used for RNAseq variants and splicing analysis, gene enrichment for immune analysis, and NetMHCpan for neoantigen and major histocompatibility complex (MHC) analysis.

Conference:

Presenting Author: Sadanandam A

Authors: Sadanandam A, Lawlor R, Larkeryd A, Mahalingam A, Mafficini A,

Keywords: Pancreatic neuroendocrine tumor, isoform switching, subtype, mutation, neoantigens, splice variant, spliceosomal mutation, immunotherapy, immunosuppression,