Surgical and multidisciplinary management of pancreatic neuroendocrine tumours with liver metastases: Insights from a high-volume centre

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Introduction: Pancreatic neuroendocrine tumours (pNETs) are rare, with liver metastases posing significant prognostic challenges. MEN1-associated pNETs often present with multifocal and complex disease, requiring a tailored, multidisciplinary approach.

Aim(s): To evaluate clinical outcomes of pNET patients with liver metastases and to outline strategies for managing MEN1-associated pNETs, focusing on surgical and systemic treatments.

Materials and methods: We retrospectively analysed data from 166 pNET patients (2015-2024), including 37 with liver metastases and 12 with MEN1. All cases were managed by a multidisciplinary team (MDT). Key analyses included demographics, tumour characteristics (Ki-67 index, T/N staging), treatment strategies (surgery, SSA, PRRT), and survival outcomes. Imaging modalities included CT, MR, FDG-PET, and Ga68-DOTATATE PET.

Conference:

Presenting Author: Yuntao B

Authors: Yuntao B, Chunhui Y, Lei L,

Keywords: Pancreatic Neuroendocrine Tumour, Liver Metastasis, MEN1, Multidisciplinary Team, Surgical Resection, Ki-67 Index, SSA, PRRT,