Survival and prognostic factors in appendiceal neuroendocrine tumors (ANET) and goblet cell carcinoma (aGCC)

#3863

Introduction: Appendiceal goblet cell carcinomas (aGCC) present with overlapping features of appendiceal neuroendocrine neoplasms (ANET) and adenocarcinomas. A previous study found that ANET with peritoneal metastases have a 5-year survival rate of 7%. Recent studies show that ANET rarely metastasizes, contrary to aGCC. The latest WHO classification excluded aGCC from the group of NETs and classified it as appendiceal adenocarcinomas.

Aim(s): The aim of this study is identifying the different disease courses between ANET and aGCC. Furthermore, prognostic factors for recurrence free survival (RFS) and disease specific survival (DSS) were identified.

Materials and methods: In this single center retrospective cohort study, patients with histopathological proven ANET or aGCC with surgery at baseline, referred to the Netherlands Cancer Institute between January 2000 and December 2019 were included. Primary endpoints were RFS and DSS. Kaplan-Meier curves and cox regression were used for survival and identification of prognostic factors.

Conference:

Presenting Author: Dijke K

Authors: Dijke K, Levy S, van den Berg J, Tesselaar M,

Keywords: Goblet cell carcinoma, Appendiceal neuroendocrine tumor, Survival,