Texture analysis of liver NET liver metastases on Ga-68 DOTATATE PET candidate to PRRT: Non-invasive histological and prognostic stratification

#3489

Introduction: Liver metastases (LM) from well-differentiated (G1/2) neuro-endocrine tumor (NET) can be managed by peptide-receptor radiotherapy (PRRT). Grading determination requires a biopsy; however, biological features can be heterogenous across metastases. Moreover, time-to-progression (TTP) after PRRT can be widely variable.

Aim(s): In this study, we tested whether texture analysis (TA) can identify features associated with histology and TTP.

Materials and methods: The institutional database was searched to identify NET patients with LM and treated with PRRT (Jan 2015 to Dec 2018). VOIs were constructed on each LM on the pre-PRRT Ga-68 DOTATATE PET (PET1) and on their counterparts on the same examination after two PRRT cycles (PET2); TTP was computed. TA was carried out with LifeX®.

Conference:

Presenting Author: Fiz F

Authors: Fiz F, Centurioni G, La Fougère C,

Keywords: PRRT, Radiomics, Texture Analysis, PET, PET/CT,