The epidemiology of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the North-East of England and a systematic review of literature

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Introduction: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare, slow-growing malignancies with unknown aetiology and an increasing incidence was observed globally. With limited research on GEP-NET epidemiology, the reasons behind incidence disparities across countries remain unclear. Whether this increase was a true phenomenon or confounded by factors including diagnostic advancement, environment, and classification evolution needs further enquiry.

Aim(s): To evaluate all available literature on GEP-NET incidence rates (IR), and to determine the IR in the North-East and the association between survival and age, gender, grade, stage, and socioeconomic status (SES).

Materials and methods: (1) Systematic review of relevant literature using MEDLINE, Embase, Scopus and Web of Science. Quality of methodology was assessed using the Newcastle-Ottawa Scale. (2) 140 GEP-NET patients in 1996-2019 were identified. Crude IR, age-standardised IR and overall survival (OS) were determined. Outcome parameters were identified from Cox-proportional Hazard analysis.

Conference:

Presenting Author:

Authors: Chu G, Robinson S, Etherson K, McNally R,

Keywords: Gastroenteropancreatic neuroendocrine tumor, Epidemiology, Incidence,