The first circulating tumor cell-derived explant (CDX) model of a Merkel cell carcinoma

#3492

Introduction: Poorly differentiated ExtraPulmonary NeuroEndocrine Carcinomas (EP-NECs) have a median overall survival of <12 months and lack effective treatments; patient-relevant preclinical models are needed.

Aim(s): In EP-NEC, to assess feasibility of liquid biopsy technologies used for the pulmonary-NEC counterpart Small Cell Lung Cancer (SCLC); circulating tumor cell (CTC) enumeration by CellSearch (CS) and CTC-Derived eXplants (CDX) which in SCLC mirror biology and chemo response of donor patients.

Materials and methods: Serial CTC enumeration and attempt at CDX generation in a prospective cohort of patients with advanced EP-NEC undergoing palliative chemotherapy (chemo).

Conference:

Presenting Author: Frizziero M

Authors: Frizziero M, Kilgour E, Simpson K, Rothwell D, Frese K,

Keywords: neuroendocrine carcinoma, Merkel cell carcinoma, circulating tumor cell, mouse model,