The relationship between MEN1 germline mutations and SSTR2 expression in neuroendocrine tumours

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Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disease characterised by the development of multiglandular parathyroid disease, pituitary tumours, and duodenopancreatic neuroendocrine tumours (NETs). Germline mutations in the tumour suppressor gene MEN1 are the underlying cause. Somatostatin receptor 2 (SSTR2) is commonly expressed by NETs. However, the expression of SSTR2 in patients with MEN1 remains unclear.

Aim(s): To investigate the correlation between MEN1 germline mutations and SSTR2 expression in NETs.

Materials and methods: NETs patients who had MEN1 germline mutations and received treatment at our centre between 2020 and 2024 were included in our retrospective analysis. Clinical data, histopathology, and SSTR2 expression were analysed.

Conference:

Presenting Author: Chi Y

Authors: Sun Y, Tan H, Wang H, Shi S, Dong L,

Keywords: multiple endocrine neoplasia type 1, somatostatin receptor 2, neuroendocrine tumour,