The Relationship Between the Ki-67 Protein and IGF-Related Genes in Gastroenteropancreatic Neuroendocrine Tumor Patients with Normal and Elevated Serum Chromogranin-A


Introduction: GEP-NETs are rare, heterogeneous neoplasms with a distinct biological and clinical behavior. Both IGF-system and Ki-67 indices have been reported as important stimulating factors in carcinogenesis and/or tumor progression. The tumor marker CgA is an independent predictor for survival as well. Currently no data are available about a possible interaction between IGF-system (IGF(-R)s, IRs, BPs) and Ki-67 protein in GEP-NET patients with normal and elevated serum CgA.

Aim(s): To investigate a possible relationship between Ki-67 index and IGF-factors in both patient groups.

Materials and methods: mRNA-expression was measured by quantitative RT-PCR. Statistical evaluations were performed with Mann-Whitney, Spearman’s rank correlation and log rank tests.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: van Adrichem R

Authors: Van Adrichem R, De Herder W, Feelders R, De Martino C, De Krijger R,

Keywords: GEP-NET,

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