The rotenone-induced rat model of Parkinson's disease: Morphological and electrophysiological findings

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Introduction: Rotenone is a pesticide, which causes behavioral, biochemical and morphological changes in rats and reproduces features of Parkinson's disease, including selective nigrostriatal dopaminergic degeneration.

Aim(s): The present study aims at providing new evidence for the validity of the rotenone rat model of PD by examining whether neuronal activity in the hippocampus is altered.

Materials and methods: The object of the current research is to investigate the effect of rotenone on synaptic transmission in hippocampus. Male albino rats were treated with rotenone injections (2.5 mg/ml intraperitoneally) for 21 days.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Hambrdzumyan L

Authors: Hambardzumyan L, Darbinyan L, Manukyan L,

Keywords: Rotenon, Parkinson's disease,