The validity of Ki-67 as a prognostic indicator in patients with appendiceal carcinoid tumor

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Introduction: Carcinoid tumors of the appendix are rare and often discovered incidentally through appendectomy. Most are clinically benign but may be associated with metastatic disease. Ki-67, a nuclear protein structurally associated with chromatin, is an excellent marker for measuring cell proliferation and it has been shown to correlate with the outcome in pancreatic and ileocecal carcinoids.

Aim(s): To examine the validity of Ki-67 as a prognostic indicator in patients with appendiceal carcinoid tumors.

Materials and methods: A retrospective chart review was conducted on 51 patients with appendiceal carcinoid tumors who underwent surgical intervention from 1991 – 2008. MIB-1, a monoclonal antibody of Ki-67 measuring its expression, was used to determine cell proliferation and correlated with clinical and histological parameters. MIB-1 index was categorized according to the WHO (World Health Organization) classification.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Liu E, Telem D, Hwang J, Warner R, Dikman S,

Keywords: Appendiceal carcinoid, Ki-67, proliferative index, correlation,