Treatment of MiNEN with peptide receptor radionuclide therapy

#4449

Introduction: Mixed non-neuroendocrine and neuroendocrine neoplasms (MiNENs) of gastrointestinal tract are rare tumours with characteristic histological features include at least 30% of both neuroendocrine and non-neuroendocrine components of the whole neoplasm. They are usually treated with surgical resection and chemotherapy in advanced disease. However, there is scarcity of data for the use of peptide receptor radionuclide therapy (PRRT) in these tumours.

Aim(s): To discuss a case of MiNENs treated with PRRT.

Materials and methods: An 82-year-old female referred to the neuroendocrine department following an incidental finding of liver lesions found on routine investigations. Radiological investigations revealed bi-lobar liver metastases with unknown primary. Histology from the liver biopsy confirmed MiNENs with the predominant component (up to 60%) being grade 2 well-differentiated NET with Ki-67 of 19% and a smaller component (up to 30%) of well to moderately differentiated adenocarcinoma of pancreaticobiliary origin. Ga DOTATATE PET/CT showed avid bi-lobar liver metastases with no extrahepatic focus of activity, and there was no FDG PET/CT avid activity within the liver metastases. Liver tumours progressed on Lancreotide 120mg Auto gel every 28 days.

Conference:

Presenting Author: Shekhda K

Authors: Shekhda K, Luong T, Paterson A, Navalkissoor S, Krell D,

Keywords: MiNEN, PRRT, DOTATATE,