Tuberous sclerosis (TSC) mutations in patients with pancreatic neuroendocrine neoplasms are associated with distinct pathological, radiological and treatment-related findings

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Introduction: Patients with pancreatic neuroendocrine neoplasms (PanNENs) can rarely harbour tuberous sclerosis (TSC) mutations but there is no knowledge on the pathological, radiological or treatment-related associations of those.

Aim(s): Describe PanNENs with TSC mutations with focus on pathology and treatment implications.

Materials and methods: Retrospective search for PanNENs and TSC mutations was sought using an existing database. Review of histology, radiological presentations and responses to standard chemotherapy was recorded.

Conference:

Presenting Author: Navale P

Authors: Navale P, Itani M, Trikalinos N,

Keywords: TSC, temozolomide, oncocytic, PanNEN,