Uncommon ophthalmic presentation of a small bowel neuroendocrine tumour: Case report

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Introduction: Neuroendocrine tumours (NETs), including carcinoid tumours, are slow-growing neoplasms commonly originating in the gastrointestinal tract or bronchus, but they can also arise in other sites. Due to their indolent nature, the majority of NETs are diagnosed at an advanced stage, typically to the lymph nodes, liver, or bones.

Aim(s): Orbital metastasis from small bowel NETs is rare, and whenit occurs, it most commonly involves the choroid rather than extraocular orbital structures.

Materials and methods: A 47-year-old woman who was diagnosed with a small bowel NET following the discovery of a retinal lesion during an ophthalmologic examination prompted by a history of visual blurring. The lesion was initially suspected to be a choroidal melanoma. Further diagnostic work-up, including imaging and biopsy, revealed a deep abdominal mass in close contact with the jejunum and proximal ileum, along with secondary hepatic lesions. Histological examination of the liver biopsy confirmed a typical carcinoid tumour, with immunohistochemistry showing positivity for chromogranin, synaptophysin, and a Ki-67 index of <1%. Octreoscan imaging demonstrated focal somatostatin receptor overexpression in the abdominal mass and additional hepatic foci. A left orbital metastasis was identified with subtle radiotracer uptake, consistent with metastatic involvement.

Conference:

Presenting Author:

Authors: Hamidatou K, Behourah Z, Ahed Messaoud M, Megaiz A, Lechar M,

Keywords: Neuroendocrine tumour, Carcinoid tumour, Orbital metastasis, somatostatin analogue injection,