Vasostatin-1 as pancreatic neuroendocrine tumor (PanNET) biomarker: A comparison between preoperative and postoperative measurements

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Introduction: No reliable biomarkers are currently available for pancreatic neuroendocrine tumors (PanNET). Vasostatin-1 (VS-1), the N-terminal fragment of Chromogranin A (CgA), seems to be more reliable than CgA as its plasma levels are not altered by proton pump inhibitors. An association between preoperative VS-1 and pathological features of aggressiveness was previously reported in a cohort of patients with resected nonfunctioning (NF)-PanNET.

Aim(s): To compare preoperative and postoperative plasma levels of VS-1 and total-CgA.

Materials and methods: Patients submitted to surgery for NF-PanNET were retrospectively screened. Those having both pre- and postoperative plasma samples (n=35) were included in the study. Plasma levels of VS-1 and total-CgA were measured by ELISA, preoperatively and on postoperative day 5 (POD5).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Andreasi V

Authors: Andreasi V, Partelli S, Manzoni M, Colombo B, Muffatti F,

Keywords: pancreatic neuroendocrine tumor, biomarker, chromogranin A, vasostatin-1,