Vitamin Supplementation and a Personalized Diet in Patients with Neuroendocrine Tumors: The DIVIT Study


Introduction: Patients with neuroendocrine tumors (NETs) are at risk for vitamin deficiencies and poor nutritional status due to excessive serotonin production, diarrhea, previous gastrointestinal surgery, and/or treatment with somatostatin analogues (SSA). Little knowledge exists about vitamin deficiency and how patients should be supported for the deficiencies they develop during their long-lasting disease.

Aim(s): To investigate if adequate vitamin supplementation and optimal personalized dietary consultation improves the proportion of patients with normal vitamin levels

Materials and methods: Patients with metastatic NET that were treated with SSA for > 6 months were enrolled in this single-center, single-arm intervention study. Patients received vitamin A, D, E, K, B12 and/or B3 supplementation when deficient. Furthermore, patients got personal dietary counseling by a dedicated NET dietician during the study period. At baseline, after 4 and 18 weeks blood or urine vitamin levels were measured.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Stelwagen J

Authors: Stelwagen J, de Hosson L, Sijtema B, van Faassen M, Kema I,

Keywords: Vitamins, nutritional support, supplementation, vitamin deficiency, single-arm intervention,

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