Chromogranin A (CgA) and PFS Outcomes in Lanreotide Autogel (LAN) in Patients with Metastatic Enteropancreatic (EP-) NETs: Data from the CLARINET Study
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Introduction: The CLARINET study showed LAN 120 mg prolonged PFS vs. placebo (PBO) in patients with metastatic EP-NETs.
Aim(s): To explore the relationship between CgA and PFS outcomes.
Materials and methods: Tumour progression (CT scan) and plasma CgA were assessed regularly over 96 wks. PFS outcomes (RECIST 1.0) and tumour response (SD/PD) were evaluated according to change in CgA from baseline to wk 12 and last value (LV) in patients with baseline levels above normal.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author:
Authors: Caplin M, Pavel M, Cwikla J, Phan A, Raderer M,
Keywords: lanreotide, biomarker,
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