Abstract Library

#4638 Prognostic role of the kynurenine/tryptophan pathway and inflammatory cytokines in neuroendocrine tumour progression: A cross-sectional analysis

Introduction: Indoleamine-2,3-dioxygenase (IDO) converts L-tryptophan (T) to L-kynurenine (K) resulting in an immunosuppressive microenvironment.

Conference:

Presenting Author: Mancini C

Authors: Mancini C, Pecora G, Salerno G, Lionetto L, Visco V,

Keywords: Neuroendocrine Tumour, tryptophan, kynurenine, cytokines, immunotherapy, Indoleamine-2-3-dioxygenase,

#4500 Effectiveness of palbociclib plus letrozole as first line therapy of metastatic breast neuroendocrine carcinoma: A case report

Introduction: Palbociclib plus endocrine therapy is the standard treatment of advanced luminal breast cancer. However, we lack data on its effectiveness in breast neuroendocrine carcinoma (NEC).

Conference:

Presenting Author:

Authors: Saidi M, Aris H, Elyebdri H, Ilham L,

Keywords: breast neuroendocrine carcinoma, CDK4/6 inhibitor, palbociclib, endocrine therapy,

#4479 Bilateral adrenal masses associated with arterial hypertension with rare and unexpected definitive histopathological diagnosis: A case report

Introduction: During the clinical approach of bilateral adrenal masses, some imaging, biochemical and clinical guidelines are established to guide the diagnosis; however, only the histopathological result is what definitively establishes the diagnosis.

Conference:

Presenting Author: Rueda M

Authors: Rueda M, Cuellar A, Tapiero-Garcia M,

Keywords: adrenal gland, adrenal mass, Cystic lymphangioma, endothelial cyst, systemic arterial hypertension,

#4256 Epigenetic prediction of aging and metabolic traits provides insight into tumor biology in multi-focal ileal neuroendocrine tumors

Introduction: Approximately half of small intestinal neuroendocrine tumors (siNETs) are multifocal, and recent investigations into the genetic architecture of these tumors have found that they are not clonal. Due to the low mutational rate and slow growing nature of these small tumors, the ‘timing’ of the development of individual tumors has not been possible.

Conference:

Presenting Author:

Authors: Webster A, Makinen N, Ecker S, Beck S, Nakakura E,

Keywords: DNA methylation, Epigenetics, Multifocal Ileal Neuroendocrine Tumor, Multifocal Small Instestinal NET, Metabolic Traits,

#4248 Tryptophan pathway metabolites as prognostic biomarkers of recurrent disease in curatively operated neuroendocrine tumor patients

Introduction: The majority of NET patients experience recurrent disease after curative surgery. There is a need for prognostic biomarkers in this patient group.

Conference:

Presenting Author: Johansen S

Authors: Johansen S, Hansen T, Goll R, Florholmen J,

Keywords: Plasma Tryptophan Metabolites, Prognostic Biomarker, Recurrent Disease after Curative Surgery,