Clinico-Pathologic and Survival Analysis of 211 GastroEnteroPancreatic G3 Neuroendocrine Carcinomas (GEP-NECs)

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Introduction: GEP-NECs show Ki67>20% and/or >20 mitoses x10 HPF. Mixed AdenoNeuroendocrine Carcinomas (MANECs) are mixed exocrine-neuroendocrine neoplasms. NECs are associated with poor prognosis but recent findings have suggested that there is a fraction of patients showing a better than expected survival rate.

Aim(s): The present study correlates the prognosis of GEP-NECs/MANECs with clinicopathologic features.

Materials and methods: 211 NECs or MANECs were evaluated by 8 expert pathologists and stratified into the following subgroups: NECs vs MANECs; ‘low proliferative’ (LP) NECs (mitoses <20 and Ki67 between 20% and 55%) vs ‘highly proliferative’ (HP) NECs (mitoses >20 and Ki67>55%) vs MANECs. Prognosis was studied through Median Overall Survival (MOS)

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Milione M

Authors: Milione M, Spada F, Maisonneuve P, Pusceddu S, Spaggiari P,

Keywords: NEC, Ki67, MANEC, PROGNOSIS,