Health-Related Quality of Life (HRQoL) with Lanreotide Autogel (LAN) 120 mg in Patients with Enteropancreatic (EP-) NETs: Post Hoc Analyses from the CLARINET Study Abstract #1193

Introduction: In CLARINET, favourable efficacy and safety with LAN in metastatic EP-NETs was associated with stable HRQoL outcomes.
Aim(s): To report exploratory post hoc analyses of treatment impact on specific aspects of HRQoL, and explore possible prognostic factors for changes in these HRQoL aspects.
Materials and methods: Patients (n=204) completed EORTC QLQ-C30 and QLQ-GI.NET21 every 12 wks. Analyses reported are: GI.NET21 endocrine (ENDO) and GI symptoms scales; QLQ-C30 physical functioning (PF) scale. Treatment effects assessed using logistic regression to determine relative odds of unchanged/improved vs deteriorated HRQoL at last value within subgroups defined by baseline (BL) characteristics. Prognostic factors (BL characteristics) assessed for unchanged/improved vs deteriorated HRQoL using exploratory logistic regression model (p<0.1 for inclusion/exclusion).
Conference: 12th Annual ENETS Conference 2015 (2015)
Category: Medical treatment - SMS analogues, interferon
Presenting Author: Martyn Caplin

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