Abstract Library

#4036 Metformin inhibits small intestinal neuroendocrine tumor proliferation in vivo

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are rare and slow-growing, with most patients being diagnosed at a late stage with distant metastases. Metformin has been hypothesized as a potential anti-tumor agent by several studies in the past few years. This has been further confirmed by experimental studies in which metformin has inhibited cancer cell growth in different cancers, and we recently demonstrated that metformin treatment repressed the cell viability of SI-NET cells and inhibited the proliferation of cell spheroids.

Conference:

Presenting Author:

Authors: Axling F, Hellman P, Norlén O, Stålberg P, Barazeghi E,

Keywords: neuroendocrine neoplasm, SI-NET, in vivo model, metformin, RNA-seq, miRNA-seq, xenograft,

#3630 Metformin suppresses small intestinal neuroendocrine tumor growth in vivo

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are rare and slow growing, but most patients are diagnosed at a late stage with distance metastases. In the past few years, several studies have reported the anti-tumor activity of metformin in different cancers, and recently we showed that metformin treatment repressed cell viability of SI-NET cells and inhibited the growth of GOT1 spheroids.

Conference:

Presenting Author:

Authors: Barazeghi E, Axling F, Hellman P, Norlén O, Stålberg P,

Keywords: neuroendocrine tumor, metformin, SI-NET xenograft,