Metformin suppresses small intestinal neuroendocrine tumor growth in vivo

#3630

Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are rare and slow growing, but most patients are diagnosed at a late stage with distance metastases. In the past few years, several studies have reported the anti-tumor activity of metformin in different cancers, and recently we showed that metformin treatment repressed cell viability of SI-NET cells and inhibited the growth of GOT1 spheroids.

Aim(s): To investigate the effect of metformin on the growth of SI-NETs in vivo, and to identify novel molecular targets to unravel mechanisms responsible for anti-tumor activity of metformin.

Materials and methods: Here we will present results of metformin treatment in a SI-NET xenograft mouse model. Immunohistochemistry and microRNA analysis will be performed on the dissected tumors.

Conference:

Presenting Author:

Authors: Barazeghi E, Axling F, Hellman P, Norlén O, Stålberg P,

Keywords: neuroendocrine tumor, metformin, SI-NET xenograft,