Abstract Library

Welcome to the open-access search for all ENETS abstracts presented at the Annual ENETS Conferences.

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ENETS Abstract Search

#3316 Evaluation of renal and hematologic toxicities of 212Pb-VMT-alpha-NET to inform the safety of alpha-particle therapy for neuroendocrine tumors

Introduction: Lead-212 (212Pb) is an attractive alpha-particle emitter for SSTR2-targeted therapy for neuroendocrine tumors. We developed a new peptide structure (VMT-alpha-NET) specifically for Pb isotopes, and preclinical studies demonstrated that the peptide significantly improved therapeutic responses in SSTR2-positive tumors in mice (including 8/10 complete responses).

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author:

Authors: Lee D, Li M, Liu D, Baumhover N, Sagastume E,

Keywords: PRRT, alpha-particle therapy, Pb-212, VMT-alpha-NET, toxicity,

#3013 Structurally-Optimized Peptide VMT-Alpha-NET Enhances the Efficacy of SSTR2-Targeted Alpha-Particle Therapy for Neuroendocrine Tumors

Introduction: 203Pb/212Pb is a promising theranostics pair for SSTR2-targeted alpha-particle therapy for neuroendocrine tumors (NETs). The development of SSTR2-targeted peptides that are optimized for the Pb isotopes has the potential to improve performance.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Lee D, Li M, Baumhover N, Liu D, Sagastume E,

Keywords: prrt, VMT-alpha-NET, 203Pb/212Pb theranostics,