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#2141 Potential Role of SST5TMD4-Derived Peptides in the Malignancy of Neuroendocrine Tumors and Other Endocrine-Related Cancer Cells

Introduction: Extracellular fragments derived from membrane receptors can play relevant functional roles in certain tumoral pathologies and could provide novel diagnostic or therapeutic tools. We have identified a novel truncated somatostatin receptor type 5 variant, sst5TMD4, which is overexpressed and functionally active in different endocrine-related cancers, including neuroendocrine tumors (NETs). Interestingly, sst5TMD4 has 4 transmembrane domains and its C-terminal tail is consequently exposed towards the extracellular matrix, and could, therefore, be the substrate for proteolytic enzymes.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Pedraza-Arévalo S, Del Río-Moreno M, Alors-Pérez E, Castaño J, Luque R,

Keywords: sst5TMD4, derived peptides, malignancy, endocrine-related cancer,

#1566 Splicing Dysregulation Impacts on Neuroendocrine Tumors: Evidence from Altered Spliceosoma Components and Somatostatin and Ghrelin Systems.

Introduction: Splicing is an emerging cancer hallmark influencing multiple tumor cell (dys)functions. We have shown that aberrantly spliced variants of somatostatin receptor subtype 5 (sst5TMD4) and of the pleiotropic neuropeptide ghrelin (in1ghrelin) are linked to poor prognosis in gastroenteropancreatic neuroendocrine tumors (GEPNETs) and may enhance their aggressiveness features.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Castaño J

Authors: Castaño J, Pedraza-Arevalo S, Herrea-Martinez A, Del Río-Moreno M, Sánchez-Sánchez R,

Keywords: Splicing,