Abstract Library

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#3535 A case series and literature review of DIPNECH

Introduction: DIPNECH is characterised by bilateral carcinoids ≤0.5cm, tumorlets

Conference:

Presenting Author:

Authors: Montebello A, Ricketts W, Druce M,

Keywords: DIPNECH, clinical presentation, diagnosis, longitudinal behaviour,

#48 Preliminary report of the use of everolimus in a patient with progressive medullary thyroid carcinoma

Introduction: Medullary thyroid carcinoma (MTC) accounts for about 5-10% of all thyroid cancers, and while disease localized to the thyroid can be cured by surgery, there is no effective treatment for disseminated MTC. Constitutive activation of the RET proto-oncogene is implicated in familial and a proportion of sporadic cases, and up-regulates the AKT/PI3-kinase/mTOR signal transduction pathway. Recent studies have shown that the inhibitor of mTOR, everolimus (RAD001, Novartis, Basel), can inhibit the proliferation of the TT cell line and human MTC tumor cells in vitro. Clinically, everolimus has been shown to attenuate the progression of some gastrointestinal neuroendocrine tumors, but its clinical use in MTC has not yet been evaluated.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Druce M, Maher K, Grozinsky-Glasberg S, Gross D, Chambers J,

Keywords: medullary thyroid cancer, calcitonin, everolimus, RAD001,