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#408 Expression of Cocaine- and Amphetamine-Regulated Transcript is Associated with Worse Survival in Small Bowel Carcinoid Tumors

Introduction: Cocaine- and amphetamine-regulated transcript (CART) peptide acts both as a neurotransmitter and hormone. We recently demonstrated that CART is expressed in several types of neuroendocrine tumors.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Landerholm K, Shcherbina L, Falkmer S, Järhult J, Wierup N,

Keywords: neuroendocrine tumor, carcinoid, CART, survival, prognostic factors,

#140 Serotonin expression in gastric neuroendocrine tumors and in foci of endocrine cell hyperplasia

Introduction: The most abundant neuroendocrine (NE) cell population of the human oxyntic mucosa is the enterochromaffin-like (ECL) cells, followed by ghrelin, somatostatin and serotonin cells, respectively. All types of ECL cell carcinoids (ECL-CCs) contain serotonin cells but in a varying frequency. Hitherto, only foci of ECL and ghrelin cell hyperplasia have been described in the peritumorous mucosa of types I and II ECL-CCs. It is established that hypergastrinaemia can cause ECL cell hyperplasia but it does not affect serotonin cells. The vesicular monoamine transporter 2 (VMAT 2) is used as an immunohistochemical marker for ECL cells.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Tsolakis A

Authors: Tsolakis A, Falkmer S, Grimelius L,

Keywords: enterochromaffin-cell carcinoids, immunohistochemistry, serotonin cell hyperplasia, VMAT 2,