Abstract Library

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#3770 Molecular imaging, molecular profiling and outcomes in patients with transformation to grade 3 neuroendocrine neoplasia (NEN)

Introduction: Transformation of Grade (G) 1-2 to G3 NEN has prognostic & therapeutic implications, but its mechanisms are unclear.

Conference:

Presenting Author: Kong G

Authors: Kong G, Prall O, Flynn A, Tothill R, Hatzimihalis A,

Keywords: G3, transformation, IHC, genomic sequencing, FDG PET/CT, P53, Rb1, mutations,

#3161 Phase 1 trial of PARP inhibitor combined with 177Lu-DOTA-Octreotate Peptide Receptor Radionuclide Therapy (PRRT) in patients with metastatic neuroendocrine tumor - PARLuNET

Introduction: 177Lu-DOTA-Octreotate (177Lu-DOTATATE) is an effective treatment for patients with grade 1 and 2 NET. However, strategies are required to optimize treatment efficacy and outcomes. Combining a DNA-repair modifying agent could further enhance radiation efficacy. Pre-clinical data supports that a PARP inhibitor (PARPi) combined with PRRT significantly enhances NET cell death and animal survival compared to 177Lu-DOTATATE alone. This combination strategy aims to enhance radiation efficacy from PRRT.

Conference: 18th Annual ENETS Concerence (2021)

Presenting Author: Kong G

Authors: Kong G, Hatzimihalis A, Hogg A, Bressel M, Hicks R,

Keywords: PRRT, PARP inhibitor, combination therapy, NET, pancreatic, phase 1,