Abstract Library

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ENETS Abstract Search

#3469 Hedgehog pathway implications in gastroenteropancreatic neuroendocrine tumors

Introduction: Hedgehog (Hh) signaling pathway has a known role in the development of various tumors and we have selective inhibitors. However, its implications in neuroendocrine tumors (NETs) are still to be unrevealed.

Conference:

Presenting Author:

Authors: Saiz-Lopez P, Alcaraz R, Blanco-Abad C, Garcia-Toro E, Garcia-Girón C,

Keywords: Hedgehog, gastroenteropancreatic, prognostic,

#453 Activation of Hedgehog Pathway in Neuroendocrine Tumor

Introduction: Neuroendocrine tumors (NETs) are rare tumors and often follow an indolent course, especially the tumors of low-to-intermediate grade. The genetic etiology of sporadic NET is largely unknown. It is well-known that a significant number of patients with NETs may have harbored the slow-growing lesions since very a young age, suggesting it could result from alterations of pathways involved in development. Hedgehog (Hh) signaling has been found to be important in embryonic patterning, stem cell maintenance and tissue repair; and is normally silenced in most mature adult tissue. However, it frequently undergoes gain-of-function mutations or reactivation due to ligand overproduction and has been linked to the etiology of a variety of tumors.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Dong M, Sangai T, Rashid A, Meric-Bernstam F, Yao J,

Keywords: neuroendocrine tumor, Hedgehog pathway, therapeutic target,