Abstract Library

#1941 Integrated Safety Analysis of Telotristat Ethyl in Patients with Carcinoid Heart Disease

Introduction: Release of serotonin by neuroendocrine tumors is associated with carcinoid heart disease (CaHD), which may pose challenges for carcinoid syndrome (CS) treatment.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Lapuerta P

Authors: Lapuerta P, Kulke M, Pavel M, Biran T, Fleming R,

Keywords: serotonin, 5-HIAA,

#1068 Telotristat Etiprate in a Subset of Carcinoid Syndrome Patients Who Have High Levels of Urinary 5-hydroxyindoleacetic Acid and Frequent Flushing

Introduction: Serotonin is a key mediator of carcinoid syndrome (CS). CS patients (pts) with high levels of urinary 5-hydroxyindoleacetic acid (u5-HIAA, a serotonin metabolite) and >3 flushing episodes/day are at increased risk of developing carcinoid heart disease (CaHD).

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Wheeler D

Authors: Wheeler D, Hörsch D, Valle J, Lapuerta P, Zambrowicz B,

Keywords: biomarker, carcinoid heart disease,