Abstract Library

#1068 Telotristat Etiprate in a Subset of Carcinoid Syndrome Patients Who Have High Levels of Urinary 5-hydroxyindoleacetic Acid and Frequent Flushing

Introduction: Serotonin is a key mediator of carcinoid syndrome (CS). CS patients (pts) with high levels of urinary 5-hydroxyindoleacetic acid (u5-HIAA, a serotonin metabolite) and >3 flushing episodes/day are at increased risk of developing carcinoid heart disease (CaHD).

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Wheeler D

Authors: Wheeler D, Hörsch D, Valle J, Lapuerta P, Zambrowicz B,

Keywords: biomarker, carcinoid heart disease,

#870 Telotristat Etiprate (TE) in a Cohort of Carcinoid Heart Disease Patients in Two Phase 2 Trials

Introduction: Serotonin is a key mediator of carcinoid syndrome (CS). High levels of urinary 5-hydroxyindoleacetic acid (u5-HIAA, a serotonin metabolite) have also been linked with carcinoid heart disease (CaHD). Telotristat etiprate (TE), a novel, oral inhibitor of serotonin synthesis, is in Phase 3 development for the treatment of CS.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Wheeler D, Kulke M, O’Dorisio T, Hörsch D, Jackson S,

Keywords: carcinoid, heart disease, serotonin, telotristat,