Abstract Library

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ENETS Abstract Search

#870 Telotristat Etiprate (TE) in a Cohort of Carcinoid Heart Disease Patients in Two Phase 2 Trials

Introduction: Serotonin is a key mediator of carcinoid syndrome (CS). High levels of urinary 5-hydroxyindoleacetic acid (u5-HIAA, a serotonin metabolite) have also been linked with carcinoid heart disease (CaHD). Telotristat etiprate (TE), a novel, oral inhibitor of serotonin synthesis, is in Phase 3 development for the treatment of CS.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Wheeler D, Kulke M, O’Dorisio T, Hörsch D, Jackson S,

Keywords: carcinoid, heart disease, serotonin, telotristat,

#849 Patient-Reported Symptom Experiences Following Participation in a Study of Telotristat Etiprate for Patients with Neuroendocrine Tumors and Diarrhea Not Adequately Controlled on Octreotide

Introduction: Telotristat etiprate (LX1606), an oral tryptophan hydroxylase (TPH) inhibitor, was recently evaluated in a dose-escalation (DE) study in patients (pts) with carcinoid tumors and diarrhea not adequately controlled on octreotide.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Kulke M

Authors: Kulke M, O’Dorisio T, Yang Q, Jackson J, Jackson S,

Keywords: carcinoid, interview, symptom improvement,

#690 Primary Lymph Node Gastrinoma or Metastatic Gastrinoma with Unidentified Primary Tumor Site?

Introduction: The existence of primary lymph node gastrinoma remains controversial.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Martin J, Tedeschi M, Jackson J, Spalding D, Goldstone A,

Keywords: gastrinoma, lymph node,

#686 Hepatic Arterial Embolization for Gastroenteropancreatic NET Liver Metastases

Introduction: Selective hepatic arterial embolization (HAE) with polyvinyl alcohol particles has been shown to be equivalent to chemoembolization for patients with hepatic gastroenteropancreatic (GEP) neuroendocrine metastases. There remains debate about its clinical effectiveness and which patients benefit from treatment.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Wilson C

Authors: Wilson C, Vallance A, Bernstone G, Williams R, Jackson R,

Keywords: hepatic arterial embolisation,

#616 Assessment of DNA Double-Strand Breaks in Blood Lymphocytes after Whole-Body Radiation Exposure in Patients with Neuroendocrine Tumors Undergoing 177Lu-Octreotate Therapy

Introduction: Peptide receptor radionuclide therapy using somatostatin receptor-binding peptides, such as 177Lu-Octreotate (LuTate), has been clinically proven to be effective in treating patients with inoperable neuroendocrine tumors. Despite the rather high radiation exposure, only few side effects have been reported. However, blood cells are very sensitive to radiation. Therefore, it is important to determine how much radiation they received. Recently, the detection by immunofluorescence of the phosphorylation of the histone variant H2AX (γ‐H2AX) has been established as a reliable and sensitive technique to monitor DNA double-strand breaks (DSBs) in blood lymphocytes.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Denoyer D

Authors: Denoyer D, Martin O, Jackson P, Johnston V, Hicks R,

Keywords: 177Lu-Octreotate, γ‐H2AX, DNA damage,