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#3381 Time to reclassify gastric carcinomas of diffuse type to neuroendocrine carcinomas

Introduction: The difference between adeno- and neuroendocrine carcinomas has been disputed for decades. Occurrence of neuroendocrine tumor cells in adenocarcinomas has been recognized, but the distinction between them has been made upon a certain number of tumor cells with a neuroendocrine marker. The number of positive cells depends upon the sensitivity of the method. Carcinogenesis generally results in loss and not gain of function. New gene expression of markers specific for a cell type seldom occurs.

Conference:

Presenting Author: Waldum H

Authors: Waldum H, Mjønes P,

Keywords: adenocarcinoma, neuroendocrine carcinoma, neuroendocrine tumor (NET), classification,